Best Medicine Season 2 is set to premiere on September 22, 2026, at 8:00 p.m. ET on FOX, marking a highly anticipated return for fans of the series. The show, starring Josh Charles, Annie Potts, Josh Segarra, Cree, and Abigail Spencer, follows a top surgeon with a secret who becomes a small-town doctor in the quirky town of Port Wenn, Maine. The news comes as a relief to viewers who have been eagerly awaiting new episodes, with the first season already available on Hulu, Disney+, and soon on Netflix. The show's unique premise, blending medical drama with small-town charm, has captivated audiences, and the second season promises to build upon this intriguing foundation. As the premiere date approaches, fans can look forward to more episodes of this engaging and thought-provoking series, leaving them eager for the next installment.